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 Center for Hyperthermia - Rhein Main
 
 
 
 
 
1. Center for Hyperthermia, Hessen
 
 
 
 
 
 
 
  Regional Deep Hyperthermia (loco-regional Electro Hyperthermia) and modern Oncology -  
  the ideal combination of Conventional Medicine and integrative Oncology.  
     
     
  The term Hyperthermia refers to the process of heating-up tumor tissue with the objective to  
  destroy tumor cells  
     
  The hyperthermal overheating process at temperatures over 104.0° F (40°C) result -among other things- in:  
     
  - damage of the tumor cell membrane  
  - hyperacidity of cancer cells (increase of responsiveness to chemo- and  
  radiation therapy)
  - generation of heat shock proteins on the surface of cancer cells  
    (identification enhancement of cancer cells as foreign cells)  
     
     
  Most important Hyperthermia methods - (Oncothermia)  
  Mastall, H. "Mit Hyperthermie Krebs wirksam bekämpfen." (How to Effectively Fight Cancer with Hyperthermia)   Naturarzt 2004;12:11-12   (1.Version)  
     
  *Whole-body Hyperthermia (extreme up to 107.6°F (42°C))  
  (complex, mainly performed in hospitals, requires intensive medical monitoring)  
     
  *Whole-body Hyperthermia (moderate from 102.2° to 104.0°F (39° to 40°C)  
  (particulary for the stimulation of the immune system)  
     
  *Superficial Hyperthermia  
  (applicable with superficial skin tumors)  
     
  *Intracavitary Perfusions - Hyperthermia  
  (with inoperable abdominal tumors)  
     
  *Prostate - Hyperthermia  
  (with prostate cancer)  
     
     
  *Regional Deep Hyperthermia (Loco-regional Electro Hyperthermia)  
  (outpatient therapy of locally confined tumors and metastases)  
     
  Mastall, H. "Mit Hyperthermie Krebs wirksam bekämpfen." (How to Effectively Fight Cancer with Hyperthermia). Naturarzt 2004;12:11-12  
     
  Mastall H. "Lebensrettendes Wissen bei der Diagnose Krebs." (Life-saving Knowledge for Cancer Diagnosis). FEM 1997; 5:13-16  
      
     
  Regional deep Hyperthermia is an important treatment in advanced  
  biological cancer therapy ( i.e. Integrative Oncology = Complementary Oncology)  
   
     
  Regional deep Hyperthermia indications:  
     
  all locally confined tumors/metastases for which surgery is no option  
  - in combination with radiation therapy  
  - in combination with systemic or regional chemotherapy  
  - in combination with radiation- and chemotherapy  
  - in combination with immunotherapy, monoclonal antibody therapy or  
     hormones  
  - Monotherapy, if chemotherapy is no option.  
     
 
Leading oncological clinics in Italy use
 
  Synchro-thermal hyperthermia devices for regional deep hyperthermia.  
     
  In Germany, one of the few synchro-thermal hyperthermia devices is actually used  
 
1. in the Juvital Hyperthermia Medical Center in Hessen.
 
 
 
 
 
 
 
  Advantages of the SYNCHRO-THERMAL hyperthermia devices: .
     
  1. flexibly malleable water-cooled energy radiators  
       
  2. that adapt to the treated body parts (e.g. head, breast, abdomen)  
       
 
 
 
          
         
  Deep Hyperthermia has 2 courses of treatment:  
     
  First, zhere are 15 one-hour treatments for the course of 5 weeks,  
   that is 3 treatments per week;  
     
  then, a second course of 10 to 12 one-hour treatments  
  following a therapy-free period.  
     
  There has to be a 1 to 2 day break between the treatments, to be able to take  
  the detected tumor cell thermotolerance (adaption to heat) into account.  
     
  Thus, 2 to 3 treatments are possible within the course of one week.  
     
     
  Regional Deep Hyperthermia  
     
  Positive treatment outcomes through Regional Deep Hyperthermia could be  
  seen in:  
     
  Lung tumors, esp. Pleural mesothelioma  
  Liver tumors  
  Pancreatic cancer  
  Stomach, colorectal, rectum cancer  
  Bladder Cancer  
  Gynaecological tumors: breast cancer, ovarial cancer, uterine cancer,  
  vaginal cancer  
  Tumors in the ear, nose and throat region, oesophagal cancer  
  Sarcoma  
  Brain tumors  
  Bone metastases  
     
      
  SIDE EFFECTS OF THE LOCO-REGIONAL ELECTRO-HYPERTHERMIA:  
       
  * Erythema of the treated part (rare)  
  * Fatigue  
  Due to the intensified amount of dying malignant cells,  
    a mild fever might occur in the days following the treatment. (Whole-body heating of 3.6°F (2°C) desirable for  
    immune stimulation)  
       
  Contraindications of loco-regional Electro Hyperthermia:  
       
  * Cardiac pacemakersand other types of pacemaker electrodes. In this case the operating    
    frequencies might be altered and cause malfunctions.  
       
  * Joint replacements may act as antennas, heat up, and lead to  
    burns, but only if metal is present in the area to-be-treated.  
       
       
  Goals of Regional Deep Hyperthermia:  
     
  A: Tumor or (progressing) metastases growth prevention  
  B: Tumor reduction, if possible to operable sizes (partial remission)  
  C: Tumor disappearance (complete remission)  
  D: Radiation and/or chemotherapy efficacy improvement  
  E: Reduction of resistance development to chemotherapeutics or reintroduction of  
      chemotherapeutics sensitivity  
     
 
Liver metastases before RTH - Liver metastases after RTH
 
 
 
 
 
         
  Liver metastases with breast cancer  
  Progressive liver metastases in metastatic breast cancer (Ed.1/96 ) receiving systemic chemotherapy treatment (4xEC). After six 1-hour long Regional Deep Hyperthermia treatments with chemotherapy continuation, a partial remission of 80% was achieved; Source:  
     
  Mastall H. "Zeit- und situationsgerechte Einsatzmodelle für komplementäre Verfahren während  
  konventionell-onkologischer Therapien" (Modern and Situation-oriented Deployment Models for Complementary Medicine during Conventional Oncology Therapies)  
  32. Medizinische Woche Baden-Baden 1998; 02.XI  
     
 
Lung metastases before RTH - lung metastases after RTH
 
 
 
 
 
 
 
 
 
 
 
Lung cancer
 
  diffuse lung metastasis of a mucinous adenocarcinoma of unknown origin (CUP-syndrome) Ed. 1/97. 2 treatments of regional chemotherapy in combination with 12 treatments of Regional Deep Hyperthermia (3x per week) resulted in complete remission; Source:  
     
  Mastall H. "Zeit- und situationsgerechte Einsatzmodelle für komplementäre Verfahren während  
  konventionell-onkologischer Therapien" (Modern and Situation-oriented Deployment Models for Complementary Medicine during Conventional Oncology Therapies).  
  32. Medizinische Woche Baden-Baden 1998; 02.XI  
     
 
Lung metastases before surgery
     
 
     
         
  Lung metastasis of colonrectal cancer (ED 11/97). Two lung metastasis treatments with Regional Deep Hyperthermia before surgery.  
  Result:  
  The postoperative reconstruction of the tumor showed a 70% necrosis (cell death) of the  
  lung metastasis; Source:  
     
  Mastall H. "Zeit- und situationsgerechte Einsatzmodelle für komplementäre Verfahren während  
  konventionell-onkologischer Therapien" (Modern and Situation-oriented Deployment Models for Complementary Medicine Methods during Conventional Oncology Therapies).  
  32. Medizinische Woche Baden-Baden 1998; 02.XI  
     
  Statement regarding Regional Deep Hyperthermia by MD. SAHIMBAS  
  Grönemeyer Institute  
  Ruhr University  
  Bochum  
     
 
"There are no inoperable tumors or metastases where
 
 
Regional Deep Hyperthermia may not be performed"
 
     
 
 
     
  Statement by  
  Prof. Dr. Anchras Szasz  
  Biotechnics Department  
  St. Istvan University, Hungary  
  Hyperthermie Symposium, 22 + 23/SEP/06, Cologne:  
     
 
"The Regional Deep Hyperthermia shows an extremely low risk, while offering
 
 
an extremely high benefit to the patients
 
 
with an excellent cost-benefit-ratio."
 
     
 
 
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