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	Center for Hyperthermia - Rhein Main

	1. Center for Hyperthermia, Hessen

	Regional Deep Hyperthermia (loco-regional Electro Hyperthermia) and modern Oncology -
	the ideal combination of Conventional Medicine and integrative Oncology.

	The term Hyperthermia refers to the process of heating-up tumor tissue with the objective to
	destroy tumor cells

	The hyperthermal overheating process at temperatures over 104.0° F (40°C) result -among other things- in:

	- damage of the tumor cell membrane
	- hyperacidity of cancer cells (increase of responsiveness to chemo- and
	radiation therapy)
	- generation of heat shock proteins on the surface of cancer cells
	(identification enhancement of cancer cells as foreign cells)

	Most important Hyperthermia methods - (Oncothermia)
	Mastall, H. "Mit Hyperthermie Krebs wirksam bekämpfen." (How to Effectively Fight Cancer with Hyperthermia) Naturarzt 2004;12:11-12 (1.Version)

	*Whole-body Hyperthermia (extreme up to 107.6°F (42°C))
	(complex, mainly performed in hospitals, requires intensive medical monitoring)

	*Whole-body Hyperthermia (moderate from 102.2° to 104.0°F (39° to 40°C)
	(particulary for the stimulation of the immune system)

	*Superficial Hyperthermia
	(applicable with superficial skin tumors)

	*Intracavitary Perfusions - Hyperthermia
	(with inoperable abdominal tumors)

	*Prostate - Hyperthermia
	(with prostate cancer)


	*Regional Deep Hyperthermia (Loco-regional Electro Hyperthermia)
	(outpatient therapy of locally confined tumors and metastases)

	Mastall, H. "Mit Hyperthermie Krebs wirksam bekämpfen." (How to Effectively Fight Cancer with Hyperthermia). Naturarzt 2004;12:11-12

	Mastall H. "Lebensrettendes Wissen bei der Diagnose Krebs." (Life-saving Knowledge for Cancer Diagnosis). FEM 1997; 5:13-16

	Regional deep Hyperthermia is an important treatment in advanced
	biological cancer therapy ( i.e. Integrative Oncology = Complementary Oncology)

	Regional deep Hyperthermia indications:

	all locally confined tumors/metastases for which surgery is no option
	- in combination with radiation therapy
	- in combination with systemic or regional chemotherapy
	- in combination with radiation- and chemotherapy
	- in combination with immunotherapy, monoclonal antibody therapy or
	hormones
	- Monotherapy, if chemotherapy is no option.

	Leading oncological clinics in Italy use
	Synchro-thermal hyperthermia devices for regional deep hyperthermia.

	In Germany, one of the few synchro-thermal hyperthermia devices is actually used
	1. in the Juvital Hyperthermia Medical Center in Hessen.

Advantages of the SYNCHRO-THERMAL hyperthermia devices:		.

1.	flexibly malleable water-cooled energy radiators

2.	that adapt to the treated body parts (e.g. head, breast, abdomen)

	Deep Hyperthermia has 2 courses of treatment:

	First, zhere are 15 one-hour treatments for the course of 5 weeks,
	that is 3 treatments per week;

	then, a second course of 10 to 12 one-hour treatments
	following a therapy-free period.

	There has to be a 1 to 2 day break between the treatments, to be able to take
	the detected tumor cell thermotolerance (adaption to heat) into account.

	Thus, 2 to 3 treatments are possible within the course of one week.

	Regional Deep Hyperthermia

	Positive treatment outcomes through Regional Deep Hyperthermia could be
	seen in:

	Lung tumors, esp. Pleural mesothelioma
	Liver tumors
	Pancreatic cancer
	Stomach, colorectal, rectum cancer
	Bladder Cancer
	Gynaecological tumors: breast cancer, ovarial cancer, uterine cancer,
	vaginal cancer
	Tumors in the ear, nose and throat region, oesophagal cancer
	Sarcoma
	Brain tumors
	Bone metastases

	SIDE EFFECTS OF THE LOCO-REGIONAL ELECTRO-HYPERTHERMIA:

	*	Erythema of the treated part (rare)
	*	Fatigue
	*	Due to the intensified amount of dying malignant cells,
		a mild fever might occur in the days following the treatment. (Whole-body heating of 3.6°F (2°C) desirable for
		immune stimulation)

	Contraindications of loco-regional Electro Hyperthermia:

	*	Cardiac pacemakersand other types of pacemaker electrodes. In this case the operating
		frequencies might be altered and cause malfunctions.

	*	Joint replacements may act as antennas, heat up, and lead to
		burns, but only if metal is present in the area to-be-treated.

	Goals of Regional Deep Hyperthermia:

	A: Tumor or (progressing) metastases growth prevention
	B: Tumor reduction, if possible to operable sizes (partial remission)
	C: Tumor disappearance (complete remission)
	D: Radiation and/or chemotherapy efficacy improvement
	E: Reduction of resistance development to chemotherapeutics or reintroduction of
	chemotherapeutics sensitivity

	Liver metastases before RTH - Liver metastases after RTH


	Liver metastases with breast cancer
	Progressive liver metastases in metastatic breast cancer (Ed.1/96 ) receiving systemic chemotherapy treatment (4xEC). After six 1-hour long Regional Deep Hyperthermia treatments with chemotherapy continuation, a partial remission of 80% was achieved; Source:

	Mastall H. "Zeit- und situationsgerechte Einsatzmodelle für komplementäre Verfahren während
	konventionell-onkologischer Therapien" (Modern and Situation-oriented Deployment Models for Complementary Medicine during Conventional Oncology Therapies)
	32. Medizinische Woche Baden-Baden 1998; 02.XI

	Lung metastases before RTH - lung metastases after RTH


	Lung cancer
	diffuse lung metastasis of a mucinous adenocarcinoma of unknown origin (CUP-syndrome) Ed. 1/97. 2 treatments of regional chemotherapy in combination with 12 treatments of Regional Deep Hyperthermia (3x per week) resulted in complete remission; Source:

	Mastall H. "Zeit- und situationsgerechte Einsatzmodelle für komplementäre Verfahren während
	konventionell-onkologischer Therapien" (Modern and Situation-oriented Deployment Models for Complementary Medicine during Conventional Oncology Therapies).
	32. Medizinische Woche Baden-Baden 1998; 02.XI

	Lung metastases before surgery


	Lung metastasis of colonrectal cancer (ED 11/97). Two lung metastasis treatments with Regional Deep Hyperthermia before surgery.
	Result:
	The postoperative reconstruction of the tumor showed a 70% necrosis (cell death) of the
	lung metastasis; Source:

	Mastall H. "Zeit- und situationsgerechte Einsatzmodelle für komplementäre Verfahren während
	konventionell-onkologischer Therapien" (Modern and Situation-oriented Deployment Models for Complementary Medicine Methods during Conventional Oncology Therapies).
	32. Medizinische Woche Baden-Baden 1998; 02.XI


	Statement regarding Regional Deep Hyperthermia by MD. SAHIMBAS
	Grönemeyer Institute
	Ruhr University
	Bochum

	"There are no inoperable tumors or metastases where
	Regional Deep Hyperthermia may not be performed"


	Statement by
	Prof. Dr. Anchras Szasz
	Biotechnics Department
	St. Istvan University, Hungary
	Hyperthermie Symposium, 22 + 23/SEP/06, Cologne:

	"The Regional Deep Hyperthermia shows an extremely low risk, while offering
	an extremely high benefit to the patients
	with an excellent cost-benefit-ratio."

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